The highly conserved PIWI-interacting RNA CRAPIR antagonizes PA2G4-mediated NF110-NF45 disassembly to promote heart regeneration in mice.

Targeting the cardiomyocyte cell cycle is a promising strategy for heart repair following injury. Here, we identify a cardiac-regeneration-associated PIWI-interacting RNA (CRAPIR) as a regulator of cardiomyocyte proliferation. Genetic ablation or antagomir-mediated knockdown of CRAPIR in mice impairs cardiomyocyte proliferation and reduces heart regenerative potential.

An analytical study for predicting incipient motion velocity of sediments under ice cover.

This study investigates the critical impact of incipient sediment motion on sediment transport estimation and riverbed evolution prediction. In this research, we examine the effects of ice cover on the vertical distribution of flow velocity, establishing a mathematical relationship between the vertical average flow velocities in open channel and ice-covered flows. This leads to the derivation of a formula for incipient motion velocity under ice cover.

Efficient and Scalable Direct Regeneration of Spent Layered Cathode Materials via Advanced Oxidation.

Among direct recycling methods for spent lithium-ion batteries, solid-state regeneration is the route with minimal bottlenecks for industrial application and is highly compatible with the current industrial cathode materials production processes. However, surface structure degradation and interfacial impurities of spent cathodes significantly hinder Li replenishment during restoration. Herein, we propose a unique advanced oxidation strategy that leverages the inherent catalytic activity of spent layered cathode materials to address these challenges.

Development of a nomogram for predicting early visual acuity outcomes and reoperation rate in patients with open globe injury.

Objective: We aimed to investigate the occurrence and factors influencing early visual acuity (VA) outcomes and reoperation rates in patients with open globe injuries (OGI) and develop a nomogram for predicting early visual acuity outcomes and reoperation rate.

Methods: We conducted a retrospective review of data from 121 patients with treated OGI. Relevant information of all patients with OGI were collected after a 1-month timeframe post-surgery.

Bio-Based Elastomers: Design, Properties, and Biomedical Applications.

To reduce carbon footprint and human dependence on fossil fuels, the field of bio-based polymers has undergone explosive growth in recent years. Among them, bio-based elastomers have gained tremendous attention for their inherent softness, high strain, and resilience. In this review, the recent progress of representative bio-based elastomers derived from molecular building blocks and biopolymers are recapitulated, with an emphasis on molecular design, synthesis approaches, and mechanical performance.