Publications by authors named "H L Jakobsen"
Article Synopsis
- The study aimed to determine the links between MRI measurements of the membranous urethra and prostate volume with urinary continence after robot-assisted radical prostatectomy (RARP).
- It involved 100 patients, examining MRI scans before and a year after surgery, measuring anatomical features and assessing urinary function using a standardized questionnaire.
- Results showed that longer membranous urethral lengths (MUL) before and after surgery were positively associated with higher continence rates, while larger prostate volumes were linked to increased urinary incontinence.
Background: Reverse causation is a challenge in many drug-cancer associations, where the cancer symptoms are potentially mistaken for drug indication symptoms. However, tools to assess the magnitude of this type of bias are currently lacking. We used a simulation-based approach to investigate the impact of reverse causation on the association between the use of topical tacrolimus and cutaneous T-cell lymphoma (CTCL) in a multinational, population-based study using topical corticosteroids (TCS) as comparator.
View Article and Find Full Text PDFArticle Synopsis
- The CAIRO4 study aimed to determine if upfront primary tumor resection (PTR) combined with systemic therapy improves overall survival in patients with synchronous unresectable metastatic colorectal cancer (mCRC).
- Conducted in The Netherlands and Denmark, the trial involved 206 patients who were randomly assigned to receive either PTR plus systemic therapy or systemic therapy alone, with the primary endpoint being overall survival.
- Results showed that median overall survival was slightly higher for the upfront PTR group (20.1 months) compared to the no PTR group (18.3 months), but the difference was not statistically significant (P = 0.32), indicating no clear benefit from adding PTR to treatment.
Background: The optimal timing of radiotherapy (RT) after radical prostatectomy for prostate cancer has been uncertain. RADICALS-RT compared efficacy and safety of adjuvant RT versus an observation policy with salvage RT for prostate-specific antigen (PSA) failure.
Patients And Methods: RADICALS-RT was a randomised controlled trial enrolling patients with ≥1 risk factor (pT3/4, Gleason 7-10, positive margins, preoperative PSA≥10 ng/ml) for recurrence after radical prostatectomy.
Objective: To explore how the use of the ProPep® Nerve Monitoring System (ProPep Surgical, Austin, TX, USA) for intraoperative specific sparing of the pudendal nerve fibres influences postoperative functional outcomes after unilateral nerve-sparing (UNS) or non-nerve-sparing (NNS) robot-assisted radical prostatectomy (RARP).
Patients And Methods: We randomised 100 men undergoing UNS or NNS RARP to ProPep nerve monitoring during RARP (intervention) or standard of care RARP (control). Functional outcomes were assessed at 3, 6, and 12 months using the International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF), the International Prostate Symptom Score, the Danish Prostate Symptom Score, the International Index of Erectile Function, the Erection Hardness Scale, and 24-h pad tests.