Modelling hepatocellular carcinoma microenvironment phenotype to evaluate drug efficacy.

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide. Treating HCC is challenging because of the poor drug effectiveness and the lack of tools to predict patient responses. To resolve these issues, we established a patient-centric spheroid model using HepG2, TWNT-1, and THP-1 co-culture, that mimics HCC phenotype.

An Array of Glucose Nanozymes That Can Selectively Detect Glucose in Whole Blood.

Achieving sensors that can sensitively and selectively quantify levels of analytes in complex biofluids such as blood remains a significant challenge. To address this, we synthesized an array of isolated carbon nanochannels on a flat gold electrode that function as molecular sieves to prevent protein fouling and eliminate the need for antifouling layers. Utilizing a two-step pulsed technique, a reductive pulse expels negative interferences and fouling molecules followed by an oxidative pulse that oxidizes glucose at the bottom of the channel and on the gold surface.

Preliminary and Intermediate-Term Results of the Novel Modification of Frozen Elephant Trunk: A Single-Center Study.

We evaluate the preliminary and intermediate-term results of Viet Duc modification of the frozen elephant trunk (FET) technique. During December 2019 and May 2023, 47 patients underwent surgery using our modification of the FET at Viet Duc University Hospital. The mean age of the patients was 56.

Bone metastasis in endocrine-related cancer: unravelling invasion and destruction.

Bone is a common and debilitating site for metastatic cancer cell expansion. Skeletal metastasis is a multistage process, with primary stages of circulating tumour cells, progressing to a dormant state in vasculature and bone marrow niches, followed by tumorigenic reactivation, proliferation, and finally bone destruction. The frequency of bone metastasis is reconciled in Paget's "seed and soil" hypothesis, where a conducive microenvironment (bone niche) is essential for cancer cell colonisation.

Characteristics of Pseudomonas aeruginosa keratitis at Ho Chi Minh eye hospital.

Background: The increasing drug resistance of Pseudomonas aeruginosa (PA) poses a serious challenge to the current treatment. Antibiograms of this pathogen often take 3-5 days, and treatment of Pseudomonas aeruginosa keratitis (PAK) is mainly based on preliminary physical examination, clinical experience, and medical guidelines. Pertinent clinical data on the causative agent and antibiotics for high efficacy are essential for early recognition and subsequent treatment.