Publications by authors named "H L DuPont"
Retraction notice to "Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial" [International Journal of Antimicrobial Agents 56 (2020), 105949].
Philippe Gautret Jean-Christophe Lagier Philippe Parola Van Thuan Hoang Line Meddeb Hervé Tissot Dupont
Int J Antimicrob Agents
December 2024
Article Synopsis
- Intestinal ischemia-reperfusion injury can lead to both large-scale (macrocirculatory) and small-scale (microcirculatory) blood flow failures, and the study aimed to test if combining a vasoconstrictor (norepinephrine) with a vasodilator (ilomedin) improves blood pressure and circulation after injury.
- The research was conducted on 21 pigs, with three groups receiving different treatments before and after a 2-hour induced small bowel ischemia followed by reperfusion, measuring various circulatory parameters and biomarkers.
- Results showed no significant differences in mean arterial pressure or cardiac index between the groups, but the combination therapy group had notably better microcirculation performance immediately after and two
Background: Invasive candidiasis/candidemia (IC/C) is associated with a substantial health economic burden driven primarily by prolonged hospital stay. The once-weekly IV echinocandin, rezafungin acetate, has demonstrated non-inferiority to caspofungin in the treatment of IC/C. This paper reports a post hoc pooled exploratory analysis of length of stay (LoS) for hospital and intensive care unit (ICU) stays in two previously published clinical trials (ReSTORE [NCT03667690] and STRIVE [NCT02734862], that compared rezafungin with daily IV caspofungin (stable patients in the caspofungin group who met relevant criteria could step down to fluconazole after 3 days or more).
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- Non-steroidal anti-inflammatory drugs (NSAIDs) are often used for managing acute postoperative pain after surgery, but their use in cardiac procedures raises concerns about risks like increased bleeding and kidney injury.
- The KETOPAIN trial aims to evaluate the effectiveness and safety of ketoprofen in treating postoperative pain in cardiac surgery patients, involving 238 participants randomized to receive either ketoprofen or a placebo after the procedure.
- The study will assess various outcomes, including pain intensity at 24 hours post-surgery, opioid consumption, complications, and quality of life up to three months afterward.