Publications by authors named "H L COLE"
Article Synopsis
- Researchers developed and studied five new iridium(III) complexes with thienyl groups to improve their performance in photodynamic therapy for cancer.
- They found that the number of thienyl units affected the complexes' light absorption and emission properties, shifting them to longer wavelengths, which is beneficial for therapy.
- In tests against melanoma and breast cancer cell lines, one complex showed significant photocytotoxicity when activated by visible light, remaining effective even under low-oxygen (hypoxic) conditions.
Immunotherapy leads to cancer eradication despite the tumor's immunosuppressive environment. Here, we used extended long-term in-vivo imaging and high-resolution spatial transcriptomics of endogenous melanoma in zebrafish, and multiplex imaging of human melanoma, to identify domains that facilitate immune response during immunotherapy. We identified crater-shaped pockets at the margins of zebrafish and human melanoma, rich with beta-2 microglobulin (B2M) and antigen recognition molecules.
View Article and Find Full Text PDFVisitors to Colter Bay Village in Grand Teton National Park were surveyed to elicit their evaluations of experimental outdoor lighting conditions. Luminaires capable of dimming and switching between two LED modules (white, blended red-white) were installed in street and parking areas. The blended red-white lamps consisted of 30 narrowband LED with a peak wavelength 623 nm and two 3000 K white LEDs.
View Article and Find Full Text PDFBackground: Excessive heat stress led to more than 400 deaths in the United States from 2011 to 2021. Common methods for heat injury prevention revolve around measurements of the environment and fail to account for the unique individual response to stressors.
Methods: An observational approach was utilized with nine helicopter-based emergency medical services personnel during emergency flights to compare core temperature readings obtained from an ingestible temperature monitoring pill and the estimated core temperature reading of the Slate Safety Band V2 wearable device.