Publications by authors named "H L Bonkovsky"
Article Synopsis
- * Samples of HDS consumed by patients were analyzed using high-performance liquid chromatography-mass spectrometry (HPLC-MS) to verify the presence of both botanical and non-botanical ingredients.
- * Results showed that in 37% of cases, chemical analysis led to higher likelihood scores for DILI attribution, indicating it enhances confidence in diagnosing such injuries from HDS, though further research is necessary to fully integrate this method into clinical practice.
Article Synopsis
- Porphyria cutanea tarda (PCT) is a skin condition primarily caused by defects in the liver enzyme uroporphyrinogen decarboxylase (UROD), with type 1 PCT being the more common form associated with risk factors like alcohol use, liver disease, and hormonal therapy.
- A case study describes an elderly man with PCT who has risk factors including heavy alcohol and tobacco use, along with a novel genetic mutation affecting UROD function.
- The identified mutation, c.224 G>C; p. Arg 75 Pro, was shown to significantly reduce UROD enzyme activity by 50%, suggesting it is a pathogenic factor contributing to the patient's condition.
Heme is a primordial macrocycle upon which most aerobic life on Earth depends. It is essential to the survival and health of nearly all cells, functioning as a prosthetic group for oxygen-carrying proteins and enzymes involved in oxidation/reduction and electron transport reactions. Heme is essential for the function of numerous hemoproteins and has numerous other roles in the biochemistry of life.
View Article and Find Full Text PDFThere are limited data on the causative agents and characteristics of drug-induced liver injury in pregnant individuals. Data from patients with drug-induced liver injury enrolled in the ongoing multicenter Drug-Induced Liver Injury Network between 2004 and 2022 and occurring during pregnancy or 6 months postpartum were reviewed and compared with cases of drug-induced liver injury in nonpregnant women of childbearing age. Among 325 individuals of childbearing age in the Drug-Induced Liver Injury Network, 16 cases of drug-induced liver injury (5%) occurred during pregnancy or postpartum.
View Article and Find Full Text PDFObjective: To describe patients with NSAID-DILI, including genetic factors associated with idiosyncratic DILI.
Methods: In DILIN, subjects with presumed DILI are enrolled and followed for at least 6 months. Causality is adjudicated by a Delphic approach.