Socio-clinical Phenotyping in Patients with Atherosclerotic Cardiovascular Disease: A Latent Class Analysis.

In a common disease population such as atherosclerotic cardiovascular disease (ASCVD), latent classes may uncover subgroups of patients that can be distinguished by combinations of several factors instead of a single factor. In this study, we sought to identify clinical, demographic, and social sub-phenotypes of ASCVD, using latent class analysis (LCA), and assess the risk of all-cause and cardiovascular mortality across the identified socio-clinical classes. LCA is a statistical technique employed to uncover hidden class divisions within a set of individuals by utilizing a mix of categorical and/or continuous observed variables.

Association of Obesity With Psychological Distress in Young Adults: Patterns by Sex and Race or Ethnicity.

Background: Recent studies have emphasized the intricate relationship between obesity and psychological distress, unraveling the complex interplay of biological, psychological, and sociocultural factors. However, a conspicuous knowledge gap persists in understanding the association between obesity severity and psychological distress, particularly in young adults, marked by limited empirical data.

Objectives: This study comprehensively investigates the link between obesity and psychological distress among young adults, emphasizing potential variations based on gender and race or ethnicity.

Unfavorable social determinants of health and risk of mortality in adults with diabetes: findings from the National Health Interview Survey.

Introduction: Understanding the role of social determinants of health as predictors of mortality in adults with diabetes may help improve health outcomes in this high-risk population. Using population-based, nationally representative data, this study investigated the cumulative effect of unfavorable social determinants on all-cause mortality in adults with diabetes.

Research Design And Methods: We used data from the 2013-2018 National Health Interview Survey, linked to the National Death Index through 2019, for mortality ascertainment.

Unfavorable social determinants of health and mortality risk by cardiovascular disease status: Findings from a National Study of United States Adults.

Background: The association between cumulative burden of unfavorable social determinants of health (SDoH) and all-cause mortality has not been assessed by atherosclerotic cardiovascular disease (ASCVD) status on a population level in the United States.

Methods: We assessed the association between cumulative social disadvantage and all-cause mortality by ASCVD status in the National Health Interview Survey, linked to the National Death Index.

Results: In models adjusted for established clinical risk factors, individuals experiencing the highest level of social disadvantage (SDoH-Q4) had over 1.

Polysocial Risk Scores: Implications for Cardiovascular Disease Risk Assessment and Management.

Purpose Of Review: To review current evidence, discuss key knowledge gaps and identify opportunities for development, validation and application of polysocial risk scores (pSRS) for cardiovascular disease (CVD) risk prediction and population cardiovascular health management.

Recent Findings: Limited existing evidence suggests that pSRS are promising tools to capture cumulative social determinants of health (SDOH) burden and improve CVD risk prediction beyond traditional risk factors. However, available tools lack generalizability, are cross-sectional in nature or do not assess social risk holistically across SDOH domains.