Publications by authors named "H Krishnamoorthy"

Triple-negative breast cancer (TNBC), known for its hostile nature and limited treatment modalities, has spurred researchers to explore novel approaches for enhancing clinical outcomes. Here, the study aimed to analyze transcriptomics data to identify immune-related hub genes associated with TNBC that might serve as prognostic biomarkers. Initially, we determined genes that were differentially expressed between TNBC and normal tissues by integrating microarray and RNA sequencing data.

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Carrier multiplication (CM) holds great promise to break the Shockley-Queisser limit of single junction photovoltaic cells. Despite compelling spectroscopic evidence of strong CM effects in halide perovskites, studies in actual perovskite solar cells (PSCs) are lacking. Herein, we reconcile this knowledge gap using the testbed CsFAMAPbSnI system exhibiting efficient CM with a low threshold of 2E (~500 nm) and high efficiency of 99.

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Immunotherapies are promising therapeutic options for the management of triple-negative breast cancer because of its high mutation rate and genomic instability. Of note, the blockade of the immune checkpoint protein PD-1 and its ligand PD-L1 has been proven to be an efficient and potent strategy to combat triple-negative breast cancer. To date, various anti-PD-1/anti-PD-L1 antibodies have been approved.

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Article Synopsis
  • - The study investigates the role of N6-methyladenosine (m6A) methylation and its regulators in osteoporosis progression, specifically focusing on the expression of methyltransferase-like 3 (METTL3) and its target gene Runt-related transcription factor 2 (Runx2) in patients with residual ridge resorption (RRR).
  • - A total of 50 participants were analyzed, with results showing that both METTL3 and Runx2 expression levels were significantly lower in the RRR group compared to healthy controls, indicating a potential link to the disease.
  • - The findings suggest that dysregulation of m6A methylation may play a role in RRR development, emphasizing the need for
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Background: N6-methyladenosine (m6A) RNA modification and its regulatory enzymes play important roles in the modulation of inflammation by regulating inflammation-related gene expression. Dysregulation of m6A has been associated with inflammatory diseases, including periodontitis. This study aimed to investigate the potential role of m6A modification and its master regulatory enzyme METTL3 in patients with peri‑implantitis.

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