Publications by authors named "H Kovarova"
Aberrant glycosylation of glycoproteins has been linked with various pathologies. Therefore, understanding the relationship between aberrant glycosylation patterns and the onset and progression of the disease is an important research goal that may provide insights into cancer diagnosis and new therapy development. In this study, we use a surface plasmon resonance imaging biosensor and a lectin array to investigate aberrant glycosylation patterns associated with oncohematological disease-myelodysplastic syndromes (MDS).
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- The study investigated how microorganisms cause corrosion in carbon steel when exposed to synthetic bentonite pore water inoculated with natural groundwater over 780 days.
- Corrosion rates were notably higher in environments with microorganisms, with localized corrosion up to 1 mm detected within the first year.
- The presence of nitrate-reducing bacteria, particularly Methyloversatilis, was linked to increased corrosion, suggesting they could pose a risk to waste canisters in nuclear repositories.
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- Human multipotent neural stem cells show promise for treating neurological disorders, but a clear profile for ideal stem cell lines that are safe and effective is still lacking.
- Using a mass spectrometry technique with selected reaction monitoring, researchers analyzed various culture conditions and measured key protein markers linked to neural differentiation.
- The developed multiplexed assay can detect different stages of neural cell development and offers a more precise and efficient method for ensuring the quality of neural stem cell lines for clinical applications compared to traditional methods.
Introduction: Central and Eastern European Proteomic Conference (CEEPC) provides a platform for researchers to discuss multi-disciplinary integrated approaches to address a range of challenges from present day viral pandemic to on-going progress in Precision Medicine. CEEPC brings together various multi-omics entwined with novel enabling technologies, thus facilitating conceptual advances from cell to society for the benefit of mankind.
Areas Covered: Proteomic methodologies, databases and software has revolutionized our ability to assess protein interactions and cellular changes, allowing the establishment of biological connections and identification of important cellular regulatory proteins and pathways previously unknown or not fully understood.
The steadily increasing incidence of malignant melanoma (MM) and its aggressive behaviour makes this tumour an attractive cancer research topic. The tumour microenvironment is being increasingly recognised as a key factor in cancer biology, with an impact on proliferation, invasion, angiogenesis and metastatic spread, as well as acquired therapy resistance. Multiple bioactive molecules playing cooperative roles promote the chronic inflammatory milieu in tumours, making inflammation a hallmark of cancer.
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