Publications by authors named "H Kovarikova"
Background: The pathogenesis of psoriasis vulgaris involves changes in DNA molecules, genomic instability, telomere attrition, and epigenetic alterations among them. These changes are also considered important mechanisms of aging in cells and tissues.
Objective: This study dealt with oxidation damage, telomere length and methylation status in DNA originating from peripheral blood of 41 psoriatic patients and 30 healthy controls.
Background: This study aims to investigate potential markers of psoriasis and aging, and to elucidate possible connections between these two processes.
Methods: The serum samples of 60 psoriatic patients and 100 controls were analysed, and the levels of four selected parameters (AGEs, RAGE, NAD, and elastin) were determined using commercial ELISA kits. Serum C-reactive protein was assayed using an immune-nephelometry method.
Recently, an increasing incidence of HPV-induced oropharyngeal squamous cell carcinoma (OPSCC) has been observed. Moreover, locoregionally advanced stages require a combined modal approach, and the prognosis is poor. Therefore, it is essential to find early diagnostic and prognostic biomarkers.
View Article and Find Full Text PDFBackground: MicroRNAs (miRNAs) are non-coding regulatory molecules 18-25 nucleotides in length that act as post-transcriptional regulators of gene expression. MiRNAs affect various biological processes including carcinogenesis. Deregulation of miRNAa expression has been described in a variety of tumors including papillary thyroid carcinoma (PTC).
View Article and Find Full Text PDFArticle Synopsis
- The study addresses the urgent need for effective biomarkers for early detection of ovarian cancer, focusing on a four-gene methylation panel that includes CDH13, HNF1B, PCDH17, and GATA4.
- The research utilized advanced methylation detection methods and found that the panel achieved an impressive sensitivity of 88.5%, successfully identifying methylation in a high percentage of both early and late-stage tumors.
- With results showing 100% specificity and a 94.4% efficiency, the study suggests the potential of this four-gene panel for diagnosing high-grade serous ovarian carcinoma, while highlighting the need to explore less invasive testing methods like plasma analysis.