Publications by authors named "H Kouros-Mehr"

Article Synopsis
  • A first-in-human study was conducted to evaluate the safety and efficacy of acapatamab, a bispecific T-cell engager targeting metastatic castration-resistant prostate cancer (mCRPC).
  • 133 patients participated, receiving varying doses of acapatamab; the most common side effect was cytokine release syndrome (CRS), noted in a large majority, particularly during the first treatment cycle.
  • Preliminary results showed some antitumor activity, with 30.4% of patients experiencing confirmed PSA responses, though the overall durable activity was limited and further evaluation is needed.
View Article and Find Full Text PDF

Introduction The elevation of aminotransferase levels is regarded as an indicator of hepatocellular injury. The objective of this study was to describe real-world incidence of elevated aminotransferase levels with or without bilirubin elevation among patients treated with immune checkpoint inhibitors (ICIs) for solid tumors. Methods This retrospective cohort study used an electronic health record database representing > 1.

View Article and Find Full Text PDF

Antibody-drug conjugates (ADCs) are a new class of therapeutics that use antibodies to deliver potent cytotoxic drugs selectively to cancer cells. CD203c, an ecto-nucleotide pyrophosphatase-phosphodiesterase 3, is overexpressed on neoplastic mast cells (MCs) in systemic mastocytosis (SM), thus representing a promising target for antibody-mediated therapy. In this study, we have found that human neoplastic MC lines (ROSA and ROSA), which express high levels of CD203c, are highly and specifically sensitive to the antiproliferative effects of an ADC against CD203c (AGS-16C3F).

View Article and Find Full Text PDF

Introduction: The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary developmental and carcinogenesis. In recent years an important role for microRNAs (miRNAs) in a myriad of cellular processes in development and in oncogenesis has emerged.

View Article and Find Full Text PDF

The Cancer Genome Atlas (TCGA) projects have advanced our understanding of the driver mutations, genetic backgrounds, and key pathways activated across cancer types. Analysis of TCGA datasets have mostly focused on somatic mutations and translocations, with less emphasis placed on gene amplifications. Here we describe a bioinformatics screening strategy to identify putative cancer driver genes amplified across TCGA datasets.

View Article and Find Full Text PDF