Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms.

Mutations of the Drosophila melanogaster insulin/IGF signaling system slow aging, while also affecting growth and reproduction. To understand this pleiotropy, we produced an allelic series of single codon substitutions in the Drosophila insulin receptor, InR. We generated InR substitutions using homologous recombination and related each to emerging models of receptor tyrosine kinase structure and function.

Cycling but not walking to work or study is associated with physical fitness, body composition and clustered cardiometabolic risk in young men.

Introduction: Active commuting is an inexpensive and accessible form of physical activity and may be beneficial to health. The aim of this study was to investigate the association of active commuting and its subcomponents, cycling and walking, with cardiometabolic risk factors, physical fitness and body composition in young men.

Methods: Participants were 776 Finnish young (26±7 years), healthy adult men.

Awareness and Knowledge of Physical Activity Recommendations in Young Adult Men.

There are only a few studies that have assessed awareness and knowledge regarding aerobic type of physical activity (PA) guidelines recommendations, while no previous studies have examined muscular type of activity recommendation guidelines. The aim was to assess knowledge and awareness and study the associations with demographic variables and physical activity and fitness. Participants were 776 young (age 26 ± 7 years) men.

60-Hour Sleep Deprivation Affects Submaximal but Not Maximal Physical Performance.

The effect of 60-h sleep deprivation (SD) on physical performance and motor control was studied. Twenty cadets were measured for aerobic performance (VO) before and immediately after the SD period. Maximal strength and EMG of the knee extensor muscles were measured before and after 60 h of SD.