Publications by authors named "H Kornfeld"

Article Synopsis
  • Tuberculosis (TB) is a major health issue in India, especially in patients with diabetes mellitus (DM), creating a serious challenge known as TB-PDM.
  • The study analyzed the effects of DM on the immune response in patients with pulmonary TB by measuring various cytokine and chemokine levels in blood samples.
  • Results revealed that coexisting TB and PDM lead to higher mycobacterial loads and increased cytokine and chemokine levels, suggesting that glycemic control is crucial for managing this complicated relationship between the two diseases.
View Article and Find Full Text PDF

We conducted a retrospective cohort study among individuals with rifampicin-resistant tuberculosis and diabetes to determine the association between metformin use and tuberculosis treatment outcomes. We found that individuals with metformin use had a significantly lower risk of poor tuberculosis treatment outcomes (adjusted RR=0.25, 95%CI 0.

View Article and Find Full Text PDF

In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.

View Article and Find Full Text PDF

Introduction: The assessment of tuberculosis (TB) treatment outcomes predominantly relies on sputum culture conversion status. To enhance treatment management, it is crucial to identify non-sputum-based biomarkers that can predict unfavorable outcomes. Cytokines are widely studied as diagnostic biomarkers for active TB.

View Article and Find Full Text PDF