Publications by authors named "H Koenen"
Continuous monitoring of acute inflammation can become a very important next step for guiding therapeutic interventions in severely ill patients. This Perspective discusses the current medical need for patients with acute inflammatory diseases and the potential of continuous biosensing technologies. First, we discuss biomarkers that could help to monitor the state of a patient with acute systemic inflammation based on theoretical studies and empirical data.
View Article and Find Full Text PDFAims/hypothesis: There is increasing evidence for heterogeneity in type 1 diabetes mellitus (T1D): not only the age of onset and disease progression rate differ, but also the risk of complications varies markedly. Consequently, the presence of different disease endotypes has been suggested. Impaired T and B cell responses have been established in newly diagnosed diabetes patients.
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- Immunological non-responders (INR) are HIV patients with persistently low CD4+ T-cell counts despite effective antiretroviral therapy, putting them at higher risk for health issues.
- A study comparing INR to immunological responders (IR) found that INR had older age, more severe HIV prior to treatment, and lower CD4+ T-cell counts, with an increase in activated and exhausted CD4+ T-cells.
- The research highlighted that INR demonstrated impaired lymphocyte cytokine production, while innate immune responses remained similar, suggesting a potential benefit of anti-PD1 therapy for this group.
Objectives: Systemic sclerosis (SSc) is characterized by multiple clinical manifestations. Vasculopathy is a main disease hallmark and ranges in severity from an exacerbated Raynaud phenomenon to pulmonary arterial hypertension (PAH). The potential involvement of the immune system in SSc-associated vascular abnormalities is not clear.
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