Plasmonic Heating of Nanostructures.

The absorption of light by plasmonic nanostructures and their associated temperature increase are exquisitely sensitive to the shape and composition of the structure and to the wavelength of light. Therefore, much effort is put into synthesizing novel nanostructures for optimized interaction with the incident light. The successful synthesis and characterization of high quality and biocompatible plasmonic colloidal nanoparticles has fostered numerous and expanding applications, especially in biomedical contexts, where such particles are highly promising for general drug delivery and for tomorrow's cancer treatment.

Platinum nanoparticles: a non-toxic, effective and thermally stable alternative plasmonic material for cancer therapy and bioengineering.

Absorption of near infrared (NIR) light by metallic nanoparticles can cause extreme heating and is of interest for instance in cancer treatment since NIR light has a relatively large penetration depth into biological tissue. Here, we quantify the extraordinary thermoplasmonic properties of platinum nanoparticles and demonstrate their efficiency in photothermal cancer therapy. Although platinum nanoparticles are extensively used for catalysis, they are much overlooked in a biological context.

The Management of Complex Pain in Children Referred to a Pain Clinic at a Tertiary Children's Hospital in Australia.

Synopsis One of the key aspects of good health care for children and young people is the prevention and management of pain. The experience of persistent pain in children and adolescents not only has a major impact on physical, emotional, social, and developmental well-being, but also impacts the broader world, which includes family, school, and social networks. The multidisciplinary pediatric pain clinic adopts a holistic approach to care through a biopsychosocial model.

Does Gastrostomy Placement With Concurrent Fundoplication Increase the Risk of Gastrostomy-related Complications?

Objective: To compare the incidence of complications with a primary gastrostomy versus gastrostomy with concurrent fundoplication and evaluating the impact of the method of gastrostomy tube placement. Neurologically impaired children were compared with neurologically normal children. Two low profile devices were compared for longevity.

The influence of flow, shear stress and adhesion molecule targeting on gold nanoparticle uptake in human endothelial cells.

The uptake of nanoparticles by endothelial cells is dependent on shear stress adaptation and flow exposure conditions. Adaptation of primary human umbilical vein endothelial cells (HUVECs) to shear stress for 24 h was associated with reduced internalisation of unmodified 80 nm spherical gold nanoparticles (AuNPs) (mean hydrodynamic size of 99 nm in culture medium) after exposure to flow conditions compared with cells that were cultured and exposed to static conditions. Under static conditions, targeting of 80 nm AuNPs conjugated with antibodies against the intracellular adhesion molecule 1 (ICAM-1) (mean hydrodynamic size of 109 nm in culture medium) markedly increased the internalisation of AuNPs in HUVECs that were activated with the tumour necrosis factor (TNF), a treatment that markedly increased the surface expression of ICAM-1.