Publications by authors named "H Kiyota"
Objective: To examine whether antimicrobial prophylaxis based on screening rectal cultures using selective media prevented acute bacterial prostatitis following transrectal prostate biopsy (TRPB).
Methods: In this multicenter, randomized controlled trial, we enrolled 403 patients undergoing TRPB with low risks of infectious complications. Patients were randomized into a cultured group (CG) or no cultured group (NCG).
Article Synopsis
- * The present study validated the score's effectiveness by comparing 116 patients with L. pneumophila CAP to 947 patients with SARS-CoV-2 Omicron CAP, finding that L. pneumophila scores were significantly higher (4 vs 1).
- * Diagnostic sensitivity and specificity for L. pneumophila CAP were notably high (90.5% sensitivity and 90.8% specificity) when using a cutoff score of ≥3 points, emphasizing the score's reliable diagnostic potential during
Synthesis of the A/D/E-ring core compounds of maoecrystal V was achieved. The key Diels-Alder reactions between tricyclic α-methylene lactones and Kitahara-Danishefsky dienes afforded the spirocyclic core compounds in a regioselective and stereoselective manner.
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- The study analyzed antimicrobial susceptibility patterns of 793 bacterial strains from patients with complicated urinary tract infections across eight species, using national surveillance data collected in Japan from July 2020 to December 2021.
- Fluoroquinolone resistance, particularly among Escherichia coli and Pseudomonas aeruginosa, has risen over the years, with levofloxacin resistance in E. coli increasing from 28.6% in 2008 to 44.5% in 2021, while MRSA vancomycin susceptibility decreased significantly.
- Extended-spectrum β-lactamase-producing strains were identified in notable proportions, with E. coli (24.8%) and Klebsiella pneumoniae (16
Third nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2020 and 2021: Antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus.
Koichiro Wada Ichiro Tsuboi Satoshi Takahashi Mitsuru Yasuda Jun Miyazaki Hiroshi Kiyota Kiyotaka Iihara
J Infect Chemother
April 2024
Article Synopsis
- A nationwide surveillance in Japan studied the antimicrobial susceptibility of bacteria in acute uncomplicated cystitis, focusing on E. coli, K. pneumoniae, and S. saprophyticus, between April 2020 and September 2021.
- The study isolated 823 bacterial strains from urine samples of 848 patients, with a majority being E. coli (92.9%), and determined susceptibility to 18 antibacterial agents.
- Results showed a concerning increase in fluoroquinolone-resistant E. coli and extended-spectrum β-lactamase (ESBL)-producing E. coli, especially in postmenopausal women, highlighting the need for clinicians to adapt their antibiotic choices due to rising resistance rates.