Publications by authors named "H Kieler"
Background: Worldwide, an increasing number of women with cancer are receiving Gonadotropin Releasing Hormone agonist (GnRHa) co-treatment during chemotherapy aiming at ovarian protection. There is divergence among guidelines, and some have recommended GnRHa co-treatment for women with breast cancer, however, the effect of GnRHa on future fertility is uncertain.
Methods: In this population-based cohort study we included all women diagnosed with cancer at ages 15-45 between July 2005 and March 2017 in Sweden, identified in the Swedish Cancer Register.
Background: Liver disorders are important adverse effects associated with antifungal drug treatment. However, the accuracy of Clinical International Classification of Diseases (ICD)-10 codes in identifying liver disorders for register based research is not well-established. This study aimed to determine the positive predictive value (PPV) of the ICD-10 codes for identifying patients with toxic liver disease, hepatic failure, and jaundice among patients with systemic antifungal treatment.
View Article and Find Full Text PDFOpioids may modulate the immune function through opioid receptors on immune cells. Long-term consequences of prenatal opioid exposure on the immune system, such as childhood asthma, are unknown. To investigate whether prenatal opioid exposure is associated with the risk of childhood asthma.
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- The study aimed to assess the risks associated with prenatal exposure to the antiepileptic drug pregabalin, focusing on adverse birth outcomes and neurodevelopmental issues in children.
- Data was collected from population-based registries across Denmark, Finland, Norway, and Sweden from 2005 to 2016, comparing outcomes between those exposed to pregabalin and those not exposed, as well as against other medications like lamotrigine and duloxetine.
- Results indicated that while there were some associations observed, such as an increased risk for stillbirth and ADHD, overall, pregabalin exposure did not significantly correlate with serious birth issues like low birth weight, preterm birth, or developmental disorders.
Most research on safety of attention-deficit/hyperactivity disorder (ADHD) medications during pregnancy concerns central nervous system stimulants, while little is known about the safety of atomoxetine, a primary treatment alternative. We assessed the prevalence of major congenital malformations overall, and cardiac malformations and limb malformations specifically, after first-trimester exposure. In this cohort study, we included all approximately 2.
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