Publications by authors named "H Khiari"
Estimated Cancer Incidence in Northern Tunisia in 2023: Northern Tunisia Cancer Registry.
Asian Pac J Cancer Prev
December 2024
Background: Cancer is a major cause of morbidity and mortality in Tunisia. The objectives of our study were to estimate the incidence level of the main cancer sites in Northern Tunisia in 2023 and to dress projections till 2040.
Methods: The population based cancer registry database of northern Tunisia was the source of cases of this study.
Objectives: The objective of this study is to assess the cost utility of the implementation of the human papillomavirus (HPV) vaccination programme in Tunisia in addition to the current cytology screening strategy. This study is very important to guide health policy decision-makers and to help them allocate their scarce healthcare resources.
Design: We used a previously described Markov model on the Online Cost Effectiveness Analysis tool programmed with R Software.
Background And Aim: As the presence of single nucleotide polymorphisms (SNPs) in the interleukin gene continues to be a major challenge in the development of effective therapies for digestive cancers, this case-control study was conducted to assess the possible influence of genotype, haplotype and diplotype for two SNPs (-1082A/G (rs1800896) and -592A/C (rs1800872)) located in the promoter region of gene on the incidence, severity and prognosis of colorectal cancer (CRC) in Tunisians.
Methods: gene SNPs were analyzed in 130 CRC cases and 165 healthy subjects (HS) using PCR-SSP.
Results: For the -1082A/G SNP, the comparison of genotype frequencies between cases and HS groups showed that the G allele significantly reduced CRC risk under the recessive model (GG vs.
Article Synopsis
- Hemodynamic restoration is crucial in sepsis management, with initial treatment focusing on achieving a mean arterial pressure (MAP) of over 65 mmHg through volume expansion and norepinephrine (NE) if needed.
- A multicenter randomized trial is underway to evaluate the effectiveness of low-dose NE in controlling shock within 6 hours in septic patients, comparing it to standard care.
- The study measures various parameters, including lactate levels and cardiac output, with the primary goal of achieving stable shock control, and aims to include at least 100 patients in each treatment group.
Epidemiological and bacterial profile of childhood meningitis in Tunisia.
Acta Microbiol Immunol Hung
July 2024
Article Synopsis
- Despite a decline in cases due to vaccination, bacterial meningitis remains a significant health issue globally, particularly for children in Tunisia.
- A study analyzed 388 confirmed pediatric bacterial meningitis cases from 2003 to 2019, showing that Streptococcus pneumoniae was the most common bacteria, followed by Neisseria meningitidis and Haemophilus influenzae.
- The introduction of the Hib vaccine significantly reduced H. influenzae cases, while antibiotic resistance remained a concern, especially among Streptococcus pneumoniae and Neisseria meningitidis strains.