Renal excretion of magnesium and trace elements during cisplatin treatment.

Plasma and urine concentrations of platinum, magnesium, zinc and copper were measured in 15 patients treated with cisplatin. The renal excretion rates of platinum, magnesium, zinc and copper were markedly increased. In plasma markedly elevated levels of platinum could be found and were accompanied by decreased concentrations of magnesium, potassium and calcium.