Publications by authors named "H Kawate"
Background: Adrenomedullin 2 (AM2) plays critical roles in regulating blood pressure and fluid balance. However, the specific involvement of AM2 in cardiac hypertrophy has not been comprehensively elucidated, warranting further investigation into its molecular mechanisms and therapeutic implications.
Methods: Cardiac hypertrophy was induced in adult mice lacking AM2 (AM2-/-) using transverse aortic constriction surgery.
Creating genetically modified (GM) animals using CRISPR/Cas mediated through the electroporation of two-cell stage embryos, rather than fertilized eggs, holds considerable potential. The full potential of genome editing using two-cell stage embryos is only beginning to be explored. We developed an improved electroporation method to prevent blastomere fusion in two-cell-stage embryos, enabling efficient genome editing.
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- - The study focused on identifying risk factors for Vitamin D deficiency (VDD) in young Japanese women and created a scoring system (ViDDPreS) to predict this deficiency.
- - Factors like residential area, season, BMI, supplement use, and dietary habits were analyzed to establish VDD risk categories (low, medium, high) based on serum vitamin D levels.
- - Results showed a high prevalence of VDD among certain demographics, prompting the need for preventive strategies and better treatment options for affected individuals.
Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils.
Biosci Biotechnol Biochem
October 2024
Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite the numerous studies on the inhibition of amyloid formation, the prevention and treatment of a majority of amyloid-related disorders are still challenging. In this study, we investigated the effects of various plant extracts on amyloid formation of α-synuclein.
View Article and Find Full Text PDFAcute respiratory distress syndrome (ARDS) is a life-threatening lung condition characterized by widespread inflammation and pulmonary edema. Adrenomedullin (AM), a bioactive peptide with various functions, is expected to be applied in treating ARDS. Its functions are regulated primarily by two receptor activity-modifying proteins, RAMP2 and RAMP3, which bind to the AM receptor calcitonin receptor-like receptor (CLR).
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