Publications by authors named "H Karunajeewa"
Article Synopsis
- This study investigates the effectiveness and safety of different primaquine dosing strategies in preventing relapsing Plasmodium vivax malaria in children under 15 years.
- A systematic review was conducted, analyzing various studies involving children treated with primaquine, focusing on those who received treatment over multiple days and were followed up for at least 28 days.
- The findings from 3514 children across 27 studies were compiled to analyze different dosing regimens, assess the risk of recurrent malaria, and evaluate tolerability and safety concerning adverse effects.
Background: Imperfect adherence is a major barrier to effective primaquine radical cure of Plasmodium vivax. This study investigated the effect of reduced adherence on the risk of P. vivax recurrence.
View Article and Find Full Text PDFPrimaquine for radical cure of malaria poses a potentially life-threatening risk of haemolysis in G6PD-deficient patients. Herein, we review five events of acute haemolytic anaemia following the administration of primaquine in four malaria trials from Indonesia, the Solomon Islands, and Vietnam. Five males aged 9 to 48 years were improperly classified as G6PD-normal by various screening procedures and included as subjects in trials of anti-relapse therapy with daily primaquine.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the safety of primaquine, a medication used to eliminate dormant liver-stage parasites of Plasmodium vivax, focusing on its impact on hemolysis risk.
- Researchers conducted a systematic review and meta-analysis of clinical studies published from 2000 to 2023, including data on patients treated with different primaquine regimens.
- The main outcome measured was the significant reduction in hemoglobin levels (more than 25% to below 7 g/dL) by day 14 post-treatment, with analysis based on the G6PD enzyme activity levels in patients.
Background: Primaquine is used to eliminate Plasmodium vivax hypnozoites, but its optimal dosing regimen remains unclear. We undertook a systematic review and individual patient data meta-analysis to investigate the efficacy and tolerability of different primaquine dosing regimens to prevent P vivax recurrence.
Methods: For this systematic review and individual patient data meta-analysis, we searched MEDLINE, Web of Science, Embase, and Cochrane Central for prospective clinical studies of uncomplicated P vivax from endemic countries published between Jan 1, 2000, and June 8, 2023.