Publications by authors named "H Karoui"
Article Synopsis
- This study explores genetic associations related to amyotrophic lateral sclerosis (ALS) and aims to provide insights into potential treatments and risk prediction.
- The researchers identified 118 genes linked to ALS using advanced statistical methods and discovered possible repurposing opportunities for six drugs, noting varying impacts of drug classes on ALS risk.
- The results suggest that new genetic analyses can enhance understanding of ALS mechanisms and improve predictions of disease risk and patient outcomes.
We evaluate the overall sensitivity gains provided by a series of eighteen nitroxide biradicals for dynamic nuclear polarization (DNP) solid-state NMR at 9.4 T and 100 K, including eight new biradicals. We find that in the best performing group the factors contributing to the overall sensitivity gains, namely the DNP enhancement, the build-up time, and the contribution factor, often compete with each other leading to very similar overall sensitivity across a range of biradicals.
View Article and Find Full Text PDFArticle Synopsis
- This research examines the behavior of two shear thinning nanofluids that flow in a micro-channel under various conditions, focusing specifically on aspects like momentum, thermal energy, mass diffusion, and entropy generation.
- The study finds that the hyperbolic tangent nanoliquid experiences better flow velocity compared to the Williamson nanofluid, although the latter exhibits higher thermal energy and concentration levels.
- Key parameters such as Grashof number and Schmitt number significantly impact fluid flow rates and the concentration of the nanoliquids, while the temperature jump condition and variable thermal conductivity influence energy distribution and irreversibility within the system.
The role of climate in the Coronavirus disease 2019 (COVID-19) transmission appears to be controversial, as reported in earlier studies. In Africa, the subject is poorly documented. In this study, over the period from January 1st, 2020 to September 31, 2022, the daily variations in cumulative confirmed cases of COVID-19 for each African country (54 countries) are modelled through time-series-based approaches and using meteorological factors as covariates.
View Article and Find Full Text PDFMitochondria-targeted coenzyme Q10 (Mito-ubiquinone, Mito-quinone mesylate, or MitoQ) was shown to be an effective antimetastatic drug in patients with triple-negative breast cancer. MitoQ, sold as a nutritional supplement, prevents breast cancer recurrence. It potently inhibited tumor growth and tumor cell proliferation in preclinical xenograft models and in vitro breast cancer cells.
View Article and Find Full Text PDF