Publications by authors named "H Kamohara"
Article Synopsis
- * Involving 29 patients, the research found that meropenem clearance is affected by patients' SOFA scores and CRRT effluent flow rates, with significant variability among individuals.
- * Based on simulations, it recommends continuous infusion doses of 1.0 to 3.0 g/d to maintain effective drug levels, aiming for different targets depending on whether the therapy is definitive or empirical.
Background/aim: Bone resolution due to tumor invasion often occurs on the surface of the jaw and is important for clinical prognosis. Although cytokines, such as TNF-α are known to impair osteoblasts, the underlying mechanism remains unclear. Protein myristoylation, a post-translational modification, plays an important role in the development of immune responses and cancerization of cells.
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- The innate immune system plays a key role in acute kidney injury (AKI), but its specific involvement in sepsis-associated AKI (SA-AKI) in humans is still not fully understood.
- A study analyzed 19 SA-AKI patients undergoing continuous renal replacement therapy, focusing on their serum cytokines, complement components, and innate immune cell types and functions.
- Findings showed that while certain immune cell proportions were similar to healthy individuals, CD56 T cells exhibited increased FasL expression and a higher percentage of perforin-positive cells, indicating their active role in SA-AKI, along with significantly reduced immune functions of monocytes.
Objective: To evaluate the effects of IM and IV administration of alfaxalone alone and in combination with medetomidine, midazolam, or both on key stress-related neurohormonal and metabolic changes in isoflurane-anesthetized cats undergoing ovariohysterectomy or castration.
Animals: 72 client-owned mixed-breed cats undergoing ovariohysterectomy or castration between October 4, 2018, and January 10, 2020.
Procedures: For each type of surgery, cats were assigned to 1 of 6 premedication protocols groups, with 6 cats/group: physiologic saline (0.
Objective: The purpose of this study was to compare the effects of pretreatment with medetomidine (Me), midazolam (Mi), and ketamine (Ke) on stress-related neurohormonal and metabolic responses in isoflurane-anesthetized cats undergoing ovariohysterectomy and castration.
Materials And Methods: We prospectively recruited 112 client-owned healthy mixed-breed cats. In both surgeries, we divided the cats into seven groups (eight cats per group): non-treatment (control), Me (50 μg/kg), Mi (0.