Publications by authors named "H Kajimoto"
Impact of resistance training and chicken intake on vascular and muscle health in elderly women.
J Cachexia Sarcopenia Muscle
February 2025
Background: Resistance training is a well-known exercise therapy for preventing and improving lacks of muscle mass, strength, and quality with advances in age; however, its effects on arterial stiffness are not beneficial. Additionally, a higher intake of protein, which is an effective nutrient for muscle health, results in lower arterial stiffness. Whether the combination of moderate to high-intensity resistance training and high-protein intake would improve muscle mass, strength, and quality and cancel the resistance training-induced increase in arterial stiffness in elderly women remains unclear.
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- Some existing medications, like statins, may help treat chemotherapy-induced peripheral neuropathy, which is often inadequately managed.
- In experiments with mice, statins were found to reduce the pain response to mechanical stimuli without affecting cold sensations.
- The beneficial effects of statins were linked to the modulation of the glutathione S-transferase (GST) pathway, which plays a role in inflammation and could offer new therapeutic options for managing neuropathy.
Kawasaki disease (KD) is a multisystem inflammatory illness of infants and young children that can result in acute vasculitis. The mechanism of coronary artery aneurysms (CAA) in KD despite intravenous gamma globulin (IVIG) treatment is not known. We performed a Whole Genome Sequencing (WGS) association analysis in a racially diverse cohort of KD patients treated with IVIG, both using AHA guidelines.
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- Kawasaki disease (KD) is a serious inflammatory condition in young children that can lead to dangerous heart issues, specifically aneurysms in coronary arteries, and the reasons for these issues despite treatment remain unclear.
- This study utilized Whole Genome Sequencing to explore genetic links to coronary artery aneurysms in a diverse group of KD patients treated with intravenous gamma globulin (IVIG), focusing on specific genetic variants.
- Results revealed significant genetic variants associated with coronary aneurysm formation, identifying 12 important genomic risk loci that may help understand the disease's progression and improve patient management.
Introduction: Kawasaki disease (KD) is a diffuse vasculitis in children. Response to high dose intravenous gamma globulin (IVIG), the primary treatment, varies according to genetic background. We sought to identify genetic loci, which associate with treatment response using whole genome sequencing (WGS).
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