Publications by authors named "H Kaito"
Article Synopsis
- The study investigates the role of iron in pediatric Immunoglobulin A nephropathy (IgAN) with macrohematuria-induced acute kidney injury (AKI) and its impact on long-term kidney health, noting that a significant percentage of adults with similar conditions develop chronic kidney disease.
- Researchers analyzed renal biopsy samples from 44 children to assess iron deposition and immune cell characteristics, finding extensive iron accumulation in children with both IgAN and AKI.
- The findings suggest that although iron builds up in the kidneys of affected children, their overall kidney function appears to remain stable, indicating a favorable prognosis for pediatric patients with this condition.
Background: Membranoproliferative glomerulonephritis (MPGN) can be divided into immune-complex MPGN (IC-MPGN) and C3 glomerulopathy (C3G), which includes dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). These conditions result from abnormalities in different complement pathways and may lead to different prognoses. However, there are limited studies describing the respective clinical courses.
View Article and Find Full Text PDFBackground: Only 80% of children with idiopathic nephrotic syndrome respond well to glucocorticoid therapy. Multidrug-resistant nephrotic syndrome (MRNS) is associated with a poor kidney prognosis. Several retrospective studies have identified rituximab as an effective treatment for MRNS; however, prospective studies are required to assess its efficacy and safety.
View Article and Find Full Text PDFBackground: Proteinuria remission is the most significant predictive factor for kidney outcome in childhood IgA nephropathy (c-IgAN). Even if proteinuria remission can be obtained, some patients have recurrence of proteinuria in the long-term.
Methods: This is a retrospective analysis of 312 cases of proteinuria remission among 538 consecutive children with biopsy-proven IgAN from 1976 to 2013.