How many phenotypes from one genotype? The case of Prion diseases.

The usual assumption, namely that the underlying biochemical reactions in an organism tend to a unique steady-state, is shown to be not always correct. There are certain pathway mechanisms (e.g.

Control analysis of transit time for free and enzyme-bound metabolites: physiological and evolutionary significance of metabolic response times.

Control analysis of transit time, defined as tau = delta/J, has previously been considered with the constraint of low enzyme concentrations compared with free pools of metabolites [Meléndez-Hevia, Torres, Sicilia and Kacser (1990) Biochem. J. 265, 195-202].