Correction: A secreted proteomic footprint for stem cell pluripotency.

[This corrects the article DOI: 10.1371/journal.pone.

Functionality appreciation in young children.

In recognition of a need to better understand children's body image, this study aimed to explore how young children describe what they appreciate about their body functionality. A total of 381 British children aged four to six years old were interviewed in a brief play-based session. We looked at the absolute number of responses children gave when asked to list all the amazing things they could do with their bodies as well as the range of responses across body functionality domains using a coding rubric.

Family Genetic Risk Communication and Reverse Cascade Testing in the BabySeq Project.

Purpose: Genomic sequencing of newborns (NBSeq) can initiate disease surveillance and therapy for children, and may identify at-risk relatives through reverse cascade testing. We explored genetic risk communication and reverse cascade testing among families of newborns who underwent exome sequencing and had a risk for autosomal dominant disease identified.

Methods: We conducted semi-structured interviews with parents of newborns enrolled in the BabySeq Project who had a pathogenic or likely-pathogenic (P/LP) variant associated with an autosomal dominant (AD) childhood- and/or adult-onset disease returned.

Developing a 3D bone model of osteosarcoma to investigate cancer mechanisms and evaluate treatments.

Osteosarcoma is the most common primary bone cancer, occurring frequently in children and young adults. Patients are treated with surgery and multi-agent chemotherapy, and despite the introduction of mifamurtide in 2011, there has been little improvement in survival for decades. 3-dimensional models offer the potential to understand the complexity of the osteosarcoma tumor microenvironment and aid in developing new treatment approaches.