Alzheimer's disease (AD) is a neurodegenerative disorder. It causes progressive degeneration of the nervous system, affecting the cognitive ability of the human brain. Over the past two decades, neuroimaging data from Magnetic Resonance Imaging (MRI) scans has been increasingly used in the study of brain pathology related to the birth and growth of AD.
View Article and Find Full Text PDFInt J Biol Macromol
February 2025
Polysaccharide-protein nanocomplexes are considered one of the desired systems to encapsulate bioactive compounds. The study prepared chitosan (CS)/genipin (GP)/zein nanoparticles with chemical cross-linkage for encapsulating and releasing curcumin. Fourier transform infrared spectra demonstrated that cross-linkage between molecules was attributed to electrostatic interactions and the formation of amido bonds and hydrogen bonding.
View Article and Find Full Text PDFThis paper investigates the behavior of fractional-order nonlinear multi-agent systems subjected to Byzantine assaults, specifically focusing on the manipulations of both sensors and actuators. We employ weighted graphs, both directed and undirected, to illustrate the system's topology. Our methodology combines algebraic graph theory with fractional-order Lyapunov techniques to develop algebraic requirements for leader-following consensus, providing a robust framework for analyzing consensus dynamics in these complex systems.
View Article and Find Full Text PDFSmart microgels (SMGs) and metal nanoparticles (MNPs)-decorated smart microgels have garnered significant attention because of their responsive behavior. Both SMGs and their hybrids are extensively used in adsorption, drug delivery, and catalysis, which can be characterized with expensive instruments. UV-Vis spectroscopy is a technique that can easily monitor these processes, and it can also identify the presence of noble metal nanoparticles, like Ag and Au, in smart microgels with the help of the surface plasmon resonance wavelength of these metals.
View Article and Find Full Text PDFWithin the intricate fabric of human physiology, cholesterol, a lipid present in cell membranes exerts a discernible effect on the concentration of the drug in human body that influence the aspects of drug pharmacokinetics. The objective of this work is to design a case study based fractional order cholesterol drug interaction model that encapsulates the nuanced dynamics inherent in the multifaceted human physiology with identification of essential variables including drug concentration K and cholesterol level γ. The strength of nonlinear autoregressive with exogenous inputs (NARX) neural networks are exploited to predict the temporal dynamics that reveal the hidden intricacies and subtle patterns within the fractional model.
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