Publications by authors named "H K Prasad"
Dysregulated pH is now recognised as a hallmark of cancer. Recent evidence has revealed that the endosomal pH regulator Na/H exchanger NHE9 is upregulated in colorectal cancer to impose a pseudo-starvation state associated with invasion, highlighting an underexplored mechanistic link between adaptive endosomal reprogramming and malignant transformation. In this study, we use a model that quantitatively captures the dynamics of the core regulatory network governing epithelial mesenchymal plasticity.
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- BoneXpert (BX) is useful for evaluating bone age (BA) and metacarpal index (MCI) in Indian children and youth with type-1 diabetes (T1D), but its application in this group had not been previously studied.
- A study of 1,272 T1D subjects revealed that BX can accurately assess BA, with minimal errors compared to established methods, and MCI showed a significant correlation with bone density measurements.
- Findings indicated that over 50% of subjects exhibited decreased MCI, highlighting the importance of monitoring factors like height and vitamin D levels, as well as the negative impact of HbA1c and T1D duration on bone health.
The objective of the present study was to isolate and characterize the VP2 gene of parvoviruses from domestic cats in India. For that, 38 fecal samples were screened by PCR with 36.84% positivity.
View Article and Find Full Text PDFChronic pancreatitis (CP) is an etiologically and genetically heterogeneous inflammatory syndrome characterised by progressive damage to the exocrine and endocrine components of the pancreas [ 1]. The multigenic paradigm of CP has sparked research in recent years [ 2]. We aimed to expand the current knowledge of genetic susceptibility of pancreatitis in patients of Indian origin.
View Article and Find Full Text PDFEndosomal acid base balance functions as a master orchestrator within the cell, engaging with many cellular pathways to maintain homeostasis. Mutations in the endosomal pH regulator Na/H exchanger NHE6 may disrupt this delicate balancing act and cause monogenic Parkinsonism. Here, gene expression studies in post-mortem substantia nigra of Parkinson's disease (PD) patients and normal controls were performed to investigate whether NHE6 represents a pathophysiological link between monogenic and sporadic PD.
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