Publications by authors named "H K Murthy"

Electrochromic devices (ECDs) are devices that change their optical properties in response to a low applied voltage. These devices typically consist of an electrochromic layer, a transparent conducting substrate, and an electrolyte. The advancement in solid-state ECDs has been driven by the need for improved durability, optical performance, and energy efficiency.

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In recent decades, poorly insulated windows have increased the energy consumption of heating and cooling systems, thus contributing to excessive carbon dioxide emissions and other related pollution issues. From this perspective, the electrochromic (EC) windows could be a tangible solution as the indoor conditions are highly controllable by these smart devices even at a low applied voltage. Literally, vanadium pentoxide (VO) is a renowned candidate for the EC application due to its multicolor appearance and substantial lithium insertion capacity.

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Patients with newly diagnosed acute myeloid leukemia (ND-AML) derive variable survival benefit from venetoclax + hypomethylating agent (Ven-HMA) therapy. The primary objective in the current study was to develop genetic risk models that are predictive of survival and are applicable at the time of diagnosis and after establishing treatment response. Among 400 ND-AML patients treated with Ven-HMA at the Mayo Clinic, 247 (62%) achieved complete remission with (CR) or without (CRi) count recovery.

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Motivation: Genomic signal processing (GSP), which transforms biomolecular sequences into discrete signals for spectral analysis, has provided valuable insights into DNA sequence, structure, and evolution. However, challenges persist with spectral representations of variable-length sequences for tasks like species classification and in interpreting these spectra to identify discriminative DNA regions.

Results: We introduce SpecGMM, a novel framework that integrates sliding window-based Spectral analysis with a Gaussian Mixture Model to transform variable-length DNA sequences into fixed-dimensional spectral representations for taxonomic classification.

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Article Synopsis
  • - Phenotypic plasticity in tumor cells allows them to adapt and change due to stressors, playing a key role in tumor progression, as illustrated by a case of a 70-year-old man with pleomorphic adenoma who developed pleomorphic liposarcoma.
  • - Sarcomas, like liposarcoma, can develop from existing pleomorphic adenomas in the parotid gland, with only a few documented cases of primary parotid liposarcoma.
  • - This case report examines the uncharted adenoma-carcinoma-sarcoma progression in pleomorphic adenomas, aiming to provide insights for treatment planning and management from a surgical oncology standpoint.
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