Publications by authors named "H K Mangat"
Article Synopsis
- - The COVID-19 pandemic has struggled due to a lack of effective antiviral treatments for SARS-CoV-2, highlighting the need for better therapeutic options.
- - Previous reliance on vaccines alone hasn't been sufficient, partly because of the virus's rapid evolution, leading researchers to explore drug repurposing as a promising strategy.
- - This study reports positive results from a multidrug therapy approach using combinations like hydroxychloroquine and azithromycin, which could help reduce drug resistance and offer new treatment avenues for COVID-19.
Article Synopsis
- Traumatic spinal injury (TSI) presents a major health challenge globally, especially in low and middle-income nations like Tanzania where road traffic accidents (RTAs) are on the rise.
- A study analyzed data from 626 patients to compare demographic and injury patterns between TSI caused by RTAs and non-RTA events, revealing that RTAs had fewer male patients and more cervical injuries.
- Despite the differences in demographics, the study found no significant variations in treatment outcomes, underscoring the need for balanced resource distribution for spinal injury care.
The ongoing advancements in CRISPR-Cas technologies can significantly accelerate the preclinical development of both and organ genome-editing therapeutics. One of the promising applications is to genetically modify donor organs prior to implantation. The implantation of optimized donor organs with long-lasting immunomodulatory capacity holds promise for reducing the need for lifelong potent whole-body immunosuppression in recipients.
View Article and Find Full Text PDFStaphylococcus aureus is a major source of bacteremia and develops several complications, causing high morbidity and mortality. Rapid identification and detection of these bacteria have become an important issue for biomedical applications. Herein, an optical method based on a modified fluorescence in situ hybridization (FISH) approach has been established using DNA hybridization technology for the swift detection of pathogenic S.
View Article and Find Full Text PDFBackground: Stroke is a second leading cause of death globally, with an estimated one in four adults suffering a stroke in their lifetime. We aimed to describe the clinical characteristics, quality of care, and outcomes in adults with stroke in urban Northwestern Tanzania.
Methods: We analyzed de-identified data from a prospective stroke registry from Bugando Medical Centre in Mwanza, the second largest city in Tanzania, between March 2020 and October 2022.