Publications by authors named "H K Knych"
Crustaceans are housed in zoos and aquariums and have also gained importance in the private sector and food industry. Shell lesions are common and often attributed to bacterial infections. However, few controlled studies have been performed evaluating antibiotics in crustaceans.
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- The study aimed to analyze how methadone moves through and is cleared from the body in domestic ferrets after being given either through an intravenous (IV) or subcutaneous (SC) method.
- Eight healthy adult ferrets were used in a crossover experiment where they received a dose of methadone, and blood samples were taken at various intervals to measure drug concentration.
- Results showed that IV methadone had a high clearance rate and a large volume of distribution, while SC administration provided high bioavailability; however, the drug's effects only lasted for a limited time after both routes of administration.
Objective: To measure and model concentrations of the analgesic L-carvone, a natural component of spearmint, over time when administered IM to sheep and to characterize L-carvone's effects on CBCs and clinical biochemistry panels.
Methods: L-carvone formulated as a 50% solution (v/v) in ethanol and propylene glycol was administered at 71.6 mg/kg IM, split between each semitendinosus muscle in 6 sheep.
Article Synopsis
- Morphine is effective for pain relief in horses, but intravenous (IV) use can cause unwanted side effects like neuroexcitation and gastrointestinal issues.
- Oral administration of morphine yields similar pain-relief potential through the metabolite M6G without the negative effects of IV administration.
- The study found that oral morphine doses provided effective pain relief comparable to IV morphine while causing less excitation and gastrointestinal disturbances, indicating the need for further research.
Objective: To assess the pharmacokinetics and sedative effects of a single administration of oral gabapentin in African cheetahs (Acinonyx jubatus) at 2 different dosages.
Methods: Adult cheetahs (n = 16) located at 3 different zoological institutions were prospectively enrolled to receive single doses of gabapentin administered at 2 different dosages (10 mg/kg and 20 mg/kg). Venipuncture was performed under behavioral restraint at predetermined time points over a 24-hour period using a sparse sampling model.