Non-neurodestructive ganglion impar blocks for coccydynia and related disorders: a systematic review and meta-analysis.

Background/importance: Chronic coccydynia is a challenging condition to manage. Conflicting evidence exists regarding the role of the ganglion impar in coccygeal nociception. When conservative treatments fail, minimally invasive interventions at the ganglion impar may be effective in providing relief.

Nutraceutical Interventions for Mitigating Skin Ageing: Analysis of Mechanisms and Efficacy.

Skin ageing is influenced by intrinsic factors such as genetics and hormones, as well as extrinsic factors like environmental exposure, ultraviolet (UV) radiation, and diet. These factors lead to biochemical, biological, and structural changes in the skin. Plant-derived compounds with antioxidant and anti-inflammatory properties have emerged as potential anti-ageing agents.

Uterine carcinosarcoma with heterologous osseous elements: a case report of an extremely rare clinical occurrence with literature review.

Carcinosarcoma is a rare and aggressive malignant neoplasm that predominantly affects elderly postmenopausal women and can involve various gynecologic organs. It is characterized by the presence of both malignant epithelial and sarcomatous components. While most uterine carcinosarcomas (UCS) are homologous (sarcomatous component consisting of elements native to the uterus), heterologous components are less common and may vary in composition.

Genetic and molecular profiling in Merkel Cell Carcinoma: Focus on MCPyV oncoproteins and emerging diagnostic techniques.

Merkel Cell Carcinoma (MCC) is an uncommon yet highly malignant form of skin cancer, frequently linked to the Merkel cell polyomavirus (MCPyV). This review comprehensively covers data from year 2000 to 2024, employing keywords such as MCC, MCPyV Oncoproteins, Immunohistochemistry, Southern Blot, Western Blot, Polymerase Chain Reaction (PCR), Digital Droplet PCR (ddPCR), Next-Generation Sequencing (NGS), and In Situ Hybridization (ISH). The search engines utilized were Google, PubMed Central, Scopus, and other journal databases like ScienceDirect.

Extraction, optimization, purification and characterization of inulin from chicory roots using conventional and greener extraction techniques.

Inulin is a natural polysaccharide that has abundant applications in the chemical, food, and pharmaceutical industries. In the present studies, extraction of inulin was attained using conventional techniques (Soxhlet) and green techniques (ultrasonication) from chicory roots. The extraction parameters were optimized using Box-Behnken design and response surface methodology (RSM).