Publications by authors named "H K Avraham"
Article Synopsis
- The study investigates whether the events of October 7, 2023, in Israel affected IVF outcomes by comparing women treated after that date with a control group treated prior.
- The researchers included 580 patients, assessing factors like age, BMI, and IVF cycle number, and found no significant differences in pregnancy rates or embryo quality between the groups.
- The results suggest that the 'October 7' events did not have an impact on the success of IVF treatments, as outcomes remained largely consistent.
Chloride determination is of great importance, as chloride plays important roles in human health, pitting corrosion, environmental processes, and agriculture. However, chloride determination by inductively coupled plasma-optical emission spectroscopy (ICP-OES), one of the premier techniques used for elemental analysis, is currently limited to specific instrument types or requires the use of additional equipment. This work presents an argentometric method for the indirect measurement of chloride, applicable to any ICP-OES instrument.
View Article and Find Full Text PDFTriple-negative breast cancer (TNBC) is associated with high mortality due to the high expression of pro-inflammatory cytokines and lack of targeted therapies. N-acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase that promotes inflammatory responses through the deactivation of Palmitoylethanolamide (PEA), an endogenous bioactive lipid mediator. Here, we examined NAAA expression in TNBC cells (MDA-MB-231 and MDA-MB-BrM2 cells) and the effects of NAAA inhibition on TNBC tumor growth, using a selective NAAA inhibitor AM11095 (IC = 20 nM).
View Article and Find Full Text PDFWhile the prevalence of breast cancer metastasis in the brain is significantly higher in triple negative breast cancers (TNBCs), there is a lack of novel and/or improved therapies for these patients. Monoacylglycerol lipase (MAGL) is a hydrolase involved in lipid metabolism that catalyzes the degradation of 2-arachidonoylglycerol (2-AG) linked to generation of pro- and anti-inflammatory molecules. Here, we targeted MAGL in TNBCs, using a potent carbamate-based inhibitor AM9928 (hMAGL IC = 9 nM) with prolonged pharmacodynamic effects (46 h of target residence time).
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