Publications by authors named "H Joyce"
Conventional spectrometer designs necessitate a compromise between their resolution and sensitivity, especially as device and detector dimensions are scaled down. Here, we report on a miniaturizable spectrometer platform where light throughput onto the detector is instead enhanced as the resolution is increased. This planar, CMOS-compatible platform is based around metasurface encoders designed to exhibit photonic bound states in the continuum, where operational range can be altered or extended simply through adjusting geometric parameters.
View Article and Find Full Text PDFNanoscale material systems are central to next-generation optoelectronic and quantum technologies, yet their development remains hindered by limited characterization tools, particularly at terahertz (THz) frequencies. Far-field THz spectroscopy techniques lack the sensitivity for investigating individual nanoscale systems, whereas in near-field THz nanoscopy, surface states, disorder, and sample-tip interactions often mask the response of the entire nanoscale system. Here, we present a THz resonance-amplified near-field spectroscopy technique that can detect subtle conductivity changes in isolated nanoscale systems─such as a single InAs nanowire─under ultrafast photoexcitation.
View Article and Find Full Text PDFArticle Synopsis
- Older adults with heart failure are at increased risk for Alzheimer’s disease and related dementia, potentially influenced by insomnia and depression.
- This study analyzed data from over 203,000 Veterans to determine how insomnia and depressive episodes affect the timing of dementia diagnosis.
- Findings showed that patients with both insomnia and depression had the quickest progression to dementia, highlighting the need for screening these conditions to improve early detection and intervention.
Article Synopsis
- The study explores the need for non-invasive methods to detect amyloid-β pathology in Alzheimer’s disease, especially with new treatments available.
- It evaluates the effectiveness of plasma tau phosphorylated at threonine-217 (P-tau217) as a potential alternative for determining eligibility for DMTs like aducanumab.
- Results indicate that elevated P-tau217 levels strongly predict Aβ positivity, suggesting that this method could efficiently identify candidates for treatment while also highlighting the complexity of cutoff levels needed for accurate diagnoses.