Publications by authors named "H Johansen-Berg"

Oligodendrocytes continue to differentiate from their precursor cells even in adulthood, a process that can be modulated by neuronal activity and experience. Previous work has indicated that conditional ablation of oligodendrogenesis in adult mice leads to learning and memory deficits in a range of behavioral tasks. The current study replicated and re-evaluated evidence for a role of oligodendrogenesis in motor learning, using a complex running wheel task.

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Article Synopsis
  • The study investigates the mouse brain's premotor areas, challenging the idea that the secondary motor cortex (M2) is the sole higher-order motor area like in humans.
  • Researchers identified three distinct premotor areas in mice: anterior-lateral motor cortex (ALM), anterior-lateral M2 (aM2), and posterior-medial M2 (pM2), each with unique structural and functional features.
  • The findings suggest that ALM closely resembles the human anterior ventral premotor areas, while aM2 and pM2 share properties with human pre-SMA and cingulate cortex, providing insights into the similarities between the motor systems of humans and mice.
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Sleep Stage Classification (SSC) is a labor-intensive task, requiring experts to examine hours of electrophysiological recordings for manual classification. This is a limiting factor when it comes to leveraging sleep stages for therapeutic purposes. With increasing affordability and expansion of wearable devices, automating SSC may enable deployment of sleep-based therapies at scale.

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Introduction: There is growing evidence that sleep is disrupted after stroke, with worse sleep relating to poorer motor outcomes. It is also widely acknowledged that consolidation of motor learning, a critical component of poststroke recovery, is sleep-dependent. However, whether the relationship between disrupted sleep and poor outcomes after stroke is related to direct interference of sleep-dependent motor consolidation processes, is currently unknown.

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