Bone fractures in children with autistic spectrum disorder.

Background: Bone fractures in children represent a source of significant disability and morbidity. Are children with autistic spectrum disorder (ASD) at an altered risk of fractures compared with typically developing children?

Methods: Using the General Practice Research Database, the authors assessed the prevalence of fractures in boys with ASD diagnosed between 2 and 8 years. A cross-sectional design was used to compare the prevalence of fractures among children with ASD and age-matched controls, conditional logistic regression to explore the relative risk of having a fracture in association with diagnosed ASD.

Comparison of prescription drug costs in the United States and the United kingdom, part 4: antibiotics in young children.

Objectives: To compare the usage and cost of antibiotics in the United States and United Kingdom in children younger than 10 years.

Methods: A follow up of some 160,000 young children enrolled in U.S.

Prevalence and incidence rates of autism in the UK: time trend from 2004-2010 in children aged 8 years.

Objectives: To update UK studies begun in the early 1990s on the annual prevalence and incidence rates of autism in children; undertaken in response to a March 2012 press release, widely covered by the media, from the US Centre for Disease Control (CDC) reporting that the autism prevalence rate in 2008 in 8-year-old US children was 1 in 88, a 78% increase from a CDC estimate in 2004. This finding suggested a continuation of the dramatic increase in children diagnosed as autistic, which occurred in the 1990s.

Design: Population study using the UK General Practice Research Database (GPRD).