Publications by authors named "H Jegham"
Short implants as an alternative to sinus lift for the rehabilitation of posterior maxillary atrophies: Systematic review and meta-analysis.
J Stomatol Oral Maxillofac Surg
February 2019
Introduction: The choice of treatment for implant rehabilitation for maxillary atrophy is crucial. It involves either between the use of short implants or performing sinus lift and the establishment of standard implants: what would be the best choice in term of survival rate and complications? We conducted a systematic review to try to answer this question.
Materials And Methods: An electronic and manual search of clinical studies (between 2007 and 2017) comparing short implants to standard implants associated with sinus lift was performed.
Unlabelled: Insufficient bone volume for dental implant placement in the maxillary anterior segment is a constant challenge in oral surgery. Several techniques have been suggested to reconstruct deficient alveolar ridges and to facilitate dental implant placement. These techniques include bone splitting osteotomy, distraction osteogenesis, inlay and onlay bone grafting.
View Article and Find Full Text PDFThe steroid nucleus is an interesting scaffold for the development of new therapeutic agents. Within the goal of identifying anticancer agents, new pregnane derivatives were prepared by using a sequence of liquid and solid-phase reactions. After we dehydrated epi-allopregnanolone in one step with diethylaminosulfur trifluoride and generated a 2,3α-epoxide, the regio- and stereo-selective aminolysis of this epoxide enabled us to obtain a 2β-piperazino-pregnane, whose secondary amine was protected as N-Fmoc-derivative.
View Article and Find Full Text PDFArticle Synopsis
- This study evaluated a new group of aminosteroids for their potential to reduce cancer cell growth.
- Seven derivatives were tested on nine cancer cell lines and two normal cell lines, showing effective growth inhibition in cancerous cells with minimal toxicity to normal cells.
- The aminosteroids caused apoptosis and cell cycle arrest in certain cancer cells, with one compound significantly reducing tumor growth in a mouse model of breast cancer.
Article Synopsis
- RM, an aminosteroid developed by our research group, exhibits significant antitumor activity against nine cancer cell lines with minimal toxicity to normal cells.
- In HL-60 leukemia cells, RM induces a G0/G1 cell cycle block and shows signs of apoptosis, evidenced by morphological changes captured through fluorescence microscopy.
- The drug triggers a caspase-dependent death receptor pathway, as indicated by the cleavage of caspases-3 and -8, and PARP, while not affecting caspase-9.