A Turing mechanism in order to explain the patchy nature of Crohn's disease.

Crohn's disease is an inflammatory bowel disease (IBD) that is not well understood. In particular, unlike other IBDs, the inflamed parts of the intestine compromise deep layers of the tissue and are not continuous but separated and distributed through the whole gastrointestinal tract, displaying a patchy inflammatory pattern. In the present paper, we introduce a toy-model which might explain the appearance of such patterns.

Singular manifolds of proteomic drivers to model the evolution of inflammatory bowel disease status.

The conditions used to describe the presence of an immune disease are often represented by interaction graphs. These informative, but intricate structures are susceptible to perturbations at different levels. The mode in which that perturbation occurs is still of utmost importance in areas such as cell reprogramming and therapeutics models.

Secondary care experiences of patients with multiple chronic conditions.

Background: This study aimed to investigate patients' experiences, beliefs and understandings of the current secondary care of patients with multiple chronic conditions (MCC) in the Netherlands.

Methods: A qualitative, interpretative description design was used. We conducted semi-structured, in-depth interviews with patients with MCC, who visited at least two physicians in Gelre Hospitals for at least two appointments in the previous year.

Refined Regularity of the Blow-Up Set Linked to Refined Asymptotic Behavior for the Semilinear Heat Equation.

We consider , a solution of which blows up at some time , where , and . Define to be the blow-up set of , that is, the set of all blow-up points. Under suitable non-degeneracy conditions, we show that if contains an -dimensional continuum for some , then is in fact a manifold.

Lower muscle density is associated with major postoperative complications in older patients after surgery for colorectal cancer.

Background: Reduced muscle density is associated with an increased risk of postoperative complications. We examined the prognostic value of muscle density as a predictor of postoperative complications in elderly patients undergoing surgery for colorectal cancer.

Methods: Patients (≥70 years) who underwent surgery for colorectal cancer between 2006 and 2013 were selected from a prospective single centre database.