Tegoprazan-Containing Versus Proton Pump Inhibitor-Containing Therapy for First-Line Eradication of : A Meta-Analysis of Randomized Controlled Trials.

Introduction: Concerns have been raised regarding the decreasing success rates of the standard treatment of (proton pump inhibitor (PPI) and two/three antibiotics) and the long-term effects carried by PPI. Despite conflicting data, Tegoprazan, a potassium-competitive acid blocker, is hypothesized to be superior to PPI for eradicating . This systematic review and meta-analysis aim to determine the superiority of Tegoprazan-containing therapy to PPI-containing therapy for eradication.

Physical Demands at Work Associated with Lower Urinary Tract Symptoms among Women: A Cross-Sectional Study.

Objective: To evaluate the relationship between physical demands at work and lower urinary tract symptoms (LUTS) among women and their effects on quality of life (QOL) and productivity.

Methods: An online survey was conducted to collect data on the demographic characteristics, physical demands at work, and LUTS of Korean women. Occupational physical activity, sitting time, musculoskeletal risk tasks, and heavy lifting were assessed as physical demands at work.

Aspirin-induced acetylation of APE1/Ref-1 enhances RAGE binding and promotes apoptosis in ovarian cancer cells.

The role of acetylated apurinic/apyrimidinic endonuclease 1/redox factor 1 (APE1/Ref-1) in ovarian cancer remains poorly understood. Therefore, this study aimed to investigate the combined effect of recombinant human APE1/Ref-1 (rhAPE1/Ref-1) and aspirin (ASA) on two ovarian cancer cells, PEO-14, and CAOV3. The viability and apoptosis of ovarian cancer cells treated with rhAPE1/Ref-1 or ASA were assessed.

Sex differences in predicting dyslipidemia using polygenic risk score with fatty liver index and fibrotic nonalcoholic steatohepatitis index.

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are recognized risk factors for dyslipidemia. Current prediction models that rely solely on dyslipidemia polygenic risk score (PRS) have certain limitations. We aimed to validate simple indexes for NAFLD and NASH as predictors of dyslipidemia using the PRS.

Korean guidelines for diagnosis and management of interstitial lung diseases: Hypersensitivity pneumonitis.

Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease characterized by heterogeneous clinical manifestations and complex diagnostic challenges. This clinical guideline aims to provide a comprehensive framework for the diagnosis and management of HP, with an emphasis on the evolving classification into fibrotic and non-fibrotic subtypes. Integrating current clinical guidelines and expert consensus, it addresses key aspects such as radiologic and histopathologic findings, diagnostic strategies, and pharmacologic management.