History of Interdental Brushes: Origins, Developments, Perspectives.

Purpose: To trace the history of interdental brushes (IDBs) from their origins to the present, highlighting their development and future prospects compared to other interdental hygiene aids.

Methods And Materials: A literature search using digital databases, manual reviews and on-site research in museums were carried out.

Results: Although extensive literature exists on toothbrushes, flosses and toothpicks, there has been no comprehensive study of IDBs.

Creation of a Systematic Interdental Brush Set Based on the Passage Hole Diameter (PHD) - An In-Vitro Study.

Purpose: This study aimed to develop a systematic interdental brush set with size distribution based on the passage hole diameter (PHD), addressing existing gaps in size selection criteria for effective interdental cleaning.

Materials And Methods: In the first step, an interdental brush set that ascends stepwise according to the PHD value was envisioned. The study was divided into three phases: (i) in-vitro determination of PHD values of a currently existing assortment on the market by 13 calibrated dental professionals, (ii) in-vitro assessment of forces during insertion, and (iii) creation and evaluation of new prototypes for missing or non-matching PHD sizes.

Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment.

Increasing evidence supports the interplay between oncogenic mutations and immune escape mechanisms. Strategies to counteract the immune escape mediated by oncogenic signaling could provide improved therapeutic options for patients with various malignancies. As mutant calreticulin (CALR) is a common driver of myeloproliferative neoplasms (MPN), we analyzed the impact of oncogenic CALRdel52 on the bone marrow (BM) microenvironment in MPN.

75 Years Ago: Discovery of Resin Adhesion to Acid-etched Enamel - A Comparison of the 1949 and 1955 Methods.

Purpose: This paper describes previously unknown details about the discovery of resin adhesion to acid-etched human enamel.

Materials And Methods: A literature review was performed through manual assessments. Primary sources revealing the discovery of resin curing on etched enamel were analyzed considering the research objectives and methodological procedure during that era, including the type of teeth used, preparatory measures, acid-etching process, type of resin and its application, and follow-up observations.

New Methods for Replacing Single Missing Teeth with Non-prep Bridges (NPBs) - A Case Series.

Purpose: Newly developed non-invasive methods for replace a missing tooth and closing single-tooth gaps in the poster- ior region using resin composite are presented.

Materials And Methods: Four different non-invasive methods and the technical procedures, materials and instruments used are presented in a case series. These include the direct intraoral insertion of composite (with and without individual shaping aids) and indirect restorations, which are fabricated conventionally or digitally and bonded.