Publications by authors named "H J Schnittler"

Background: A multitude of vascular anomalies exist and can lead to severe complications. Treatment can be complex.

Objective: This overview aims to provide important information for the management of vascular anomalies.

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Endothelial cells (ECs) lining blood vessels are exposed to mechanical forces, such as shear stress. These forces control many aspects of EC biology, including vascular tone, cell migration and proliferation. Despite a good understanding of the genes responding to shear stress, our insight into the transcriptional regulation of these genes is much more limited.

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The various psychological dimensions of professional identity formation (PIF) are an important aspect of the study course for undergraduate medical students. Anatomical learning environments have been repeatedly shown to play a critical role in forming such an identity; however, relevance of PIF during sonoanatomical training remains underexplored. At the end of their basic anatomy studies, third-semester medical students took part in a four-day block course on anatomy and imaging.

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Junctional adhesion molecule (JAM)-A is a cell adhesion receptor localized at epithelial cell-cell contacts with enrichment at the tight junctions. Its role during cell-cell contact formation and epithelial barrier formation has intensively been studied. In contrast, its role during collective cell migration is largely unexplored.

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Article Synopsis
  • Lasp1 is a protein linked to breast cancer and tumor invasion, but its regulatory role in aggressive cell transformation is not fully understood.
  • This study reveals that Lasp1 is connected to chronic inflammatory arthritis and plays a crucial role in cell-to-cell interactions involving Cadherin-11 and β-Catenin in synoviocytes from patients and mouse models.
  • Blocking or removing Lasp1 impacts tissue formation and inflammation, indicating it may be a potential therapeutic target for treating severe inflammatory joint conditions.
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