Publications by authors named "H J Schlitt"
Background: Routine liver function tests capture information about the metabolic and inflammatory condition of the liver, but we lack sensitive biomarkers of early hepatocyte stress. In humans, soluble CD46 (sCD46) levels in blood were recently identified as an accurate biomarker of hepatic steatosis. Here, we explore the diagnostic utility of sCD46 in other liver diseases.
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- Living donor liver transplantation (LDLT) shows better outcomes than deceased donor options, but evaluation processes vary significantly across transplant centers.
- In a study of 317 potential donors, the most common reasons for rejection included liver size (40.3%) and metabolic issues like obesity (20.8%), with advanced imaging techniques identifying a majority of ineligible donors.
- The authors propose a streamlined 4-step evaluation method that could identify nearly 90% of unsuitable donors early on, improving efficiency and reducing strain on both resources and potential donors.
Biliary complications are still a major cause for morbidity and mortality after liver transplantation (LT). Ischemia/reperfusion injury (IRI) leads to disruption of the biliary epithelium. We introduce a novel model to study the effect of IRI on human cholangiocytes using extrahepatic cholangiocyte organoids (ECOs).
View Article and Find Full Text PDFFibrosis resulting from pathological repair secondary to recurrent or persistent tissue damage often leads to organ failure and mortality. Biliary fibrosis is a crucial but easily neglected pathological feature in hepatobiliary disorders, which may promote the development and progression of benign and malignant biliary diseases through pathological healing mechanisms secondary to biliary tract injuries. Elucidating the etiology and pathogenesis of biliary fibrosis is beneficial to the prevention and treatment of biliary diseases.
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