Assessing aesthetic outcomes of different incision types for nipple-sparing mastectomy followed by radiation therapy in prepectoral direct-to-implant breast reconstruction: a retrospective study.

Background: This study analyzes the aesthetic outcomes associated with inframammary fold (IMF) incisions compared to radial incisions, with or without a periareolar component (referred to as periareolar/radial, PR), considering nipple-sparing mastectomy (NSM) followed by prepectoral direct-to-implant (DTI) reconstruction and subsequent post-mastectomy radiotherapy (PMRT). We assessed changes in breast and nipple symmetry, nipple-to-IMF distance, and nipple Y-axis coefficients to understand how different incisions influence post-radiation aesthetic outcomes.

Methods: Forty patients who underwent NSM and prepectoral DTI reconstruction followed by PMRT between September 2019 and December 2022 in a single institution were included.

Metabolic Reprogramming into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived from Prostate Cancer Cells.

Most cancer cells adopt a less efficient metabolic process of aerobic glycolysis with high level of glucose uptake followed by lactic acid production, known as the Warburg effect. This phenotypic transition enables cancer cells to achieve increased cellular survival and proliferation in a harsh low-oxygen tumor microenvironment. Also, the resulting acidic microenvironment causes inactivation of the immune system such as T-cell impairment that favors escape by immune surveillance.

Effects of patient safety education programs on nursing students' knowledge, attitude, and competency with patient safety: A systematic review, meta-analysis, and meta-regression.

Aims: Patient safety is a global concern, and nurses, as the largest group of healthcare professionals, play a critical role in ensuring patient safety. This study aimed to systematically review and analyze the effects of patient safety education programs on nursing students' knowledge, attitudes, and competencies by synthesizing existing research and identifying key factors contributing to program effectiveness.

Design: Systematic review and meta-analysis.

The regulatory role of ACP5 in the diesel exhaust particle-induced AHR inflammatory signaling pathway in a human bronchial epithelial cell line.

Exposure to diesel exhaust particles (DEPs), which are major constituents of urban air pollution, is associated with adverse health outcomes. Previous studies have shown that DEPs enhance the expression of pro-inflammatory cytokines and immune responses. However, few studies have focused on genomic variants that regulate DEP-induced signaling.

Improved Limit on Neutrinoless Double Beta Decay of ^{100}Mo from AMoRE-I.

AMoRE searches for the neutrinoless double beta decay using 100 kg of enriched ^{100}Mo. Scintillating molybdate crystals coupled with a metallic magnetic calorimeter operate at milli-Kelvin temperatures to measure the energy of electrons emitted in the decay. AMoRE-I is a demonstrator for the full-scale AMoRE, operated at the Yangyang Underground Laboratory for over two years.