Electron transfer bifurcation enables biological systems to drive unfavourable (endergonic) electron transfer by coupling it to favourable (exergonic) transfer of a second electron. In electron transfer flavoproteins (ETFs), a domain-scale conformational change is believed to sever the favourable pathway after a single electron has used it, thereby preventing the energy dissipation that would accompany exergonic transfer of the second electron. To understand the conformation change that participates in turnover, we have deployed small-angle neutron scattering (SANS) and computational techniques to characterize the bifurcating ETF from (ETF).
View Article and Find Full Text PDFImportance: Meal timing strategies, such as time-restricted eating (TRE), reducing meal frequency, or altering calorie distribution across the day, have gained interest for their potential to enhance weight loss and metabolic health, particularly in managing chronic diseases, yet their long-term benefits are not known.
Objective: To evaluate the association between meal timing strategies (≥12 weeks) and anthropometric and metabolic indicators.
Data Sources: Medline, Embase, CINAHL, and Cochrane CENTRAL were searched from inception to October 17, 2023.
The magnificent catshark Proscyllium magnificum was described in 2004 based off five specimens collected in the Andaman Sea off Myanmar. It was originally allocated to the genus Proscyllium, but recent molecular analyses suggested it was more closely related to the harlequin catshark Ctenacis fehlmanni from the western Indian Ocean. This study incorporated meristics and external and internal morphology, together with molecular data to reclassify the magnificent catshark as Ctenacis magnificum and provides revised diagnoses for the genera Ctenacis and Proscyllium.
View Article and Find Full Text PDFMany of the egg cases of oviparous chondrichthyans remain unknown and undescribed in the literature. Egg cases can be a useful taxonomic character for species distinction and can be a valuable indicator of a species distribution in the field. In this study, the egg cases for 9 of the 10 nominal species of Heterodontus are described and compared, and the terminology and methodology for studying them are standardized.
View Article and Find Full Text PDF