Publications by authors named "H J Nolte"
Article Synopsis
- The study focuses on the effectiveness of a sublingual immunotherapy (SLIT) tablet for treating house dust mite-induced allergic rhinitis in children aged 5-11 years, addressing a gap in existing data for this age group.
- Conducted as a Phase III randomized trial, 1460 children were divided into two groups: one receiving the SLIT tablet and the other receiving a placebo, with significant improvements observed in allergy symptoms and quality of life for the SLIT group.
- Results showed a notable 22% reduction in the total combined rhinitis score for the SLIT group compared to placebo, alongside improved scores in other related outcome measures, suggesting SLIT's potential as an effective
Article Synopsis
- Post-hepatectomy liver failure (PHLF) poses a major risk for patients after partial liver surgery, with a need for better prognostic markers and treatments to boost liver recovery.
- A study analyzed plasma samples from nine hepatocellular carcinoma (HCC) patients before and after surgery to identify proteins in extracellular vesicles (EVs) that might indicate liver regeneration status.
- The findings revealed significant changes in protein levels in patients with PHLF, highlighting disruptions in critical cellular processes and suggesting potential biomarkers that were present before the surgery.
The initially homogeneous epithelium of the early embryo differentiates into regional subpopulations with different behaviours and physical properties that are needed for morphogenesis. The factors at top of the genetic hierarchy that control these behaviours are known, but many of their targets are not. To understand how proteins work together to mediate differential cellular activities, we studied in an unbiased manner the proteomes and phosphoproteomes of the three main cell populations along the dorso-ventral axis during gastrulation using mutant embryos that represent the different populations.
View Article and Find Full Text PDFArticle Synopsis
- MG-PRCA is a condition where the bone marrow fails to produce enough red blood cells due to the presence of abnormal proteins from monoclonal plasma cell disorders, leading to anemia.
- Patients typically show low reticulocyte counts and have normocytic, normochromic anemia as a result.
- The case discussed highlights successful treatment using a combination of isatuximab, pomalidomide, and dexamethasone after previous treatments had failed.
Introduction: A child's fear of needles may impact the preferred route of allergy immunotherapy (AIT) when choosing between subcutaneous immunotherapy (allergy shots) or sublingual immunotherapy (SLIT). A survey was conducted to understand caregiver health-seeking behavior for children with allergic rhinitis with or without conjunctivitis (AR/C) and explore if fear of needles impacted AIT decisions.
Methods: Caregivers of children ages 5-17 years with AR/C were recruited from the Dynata US research panel to participate in an online survey from May-June 2023.