Publications by authors named "H J Morbach"
Objective: Pulmonary involvement in chronic nonbacterial osteomyelitis (CNO) is rare. Limited awareness results in diagnostic challenges, especially because malignancy or infection needs to be considered.
Methods: Based on a survey shared among centers participating in the Kerndokumentation Deutsches Rheumaforschungszentrum (Germany), this study investigated clinical and imaging presentations, demographic features, treatment response and outcomes of pulmonary involvement in CNO (pCNO).
Introduction: Respiratory viral infections (RVIs) are a major global contributor to morbidity and mortality. The susceptibility and outcome of RVIs are strongly age-dependent and show considerable inter-population differences, pointing to genetically and/or environmentally driven developmental variability. The factors determining the age-dependency and shaping the age-related changes of human anti-RVI immunity after birth are still elusive.
View Article and Find Full Text PDFBackground: Inborn errors of immunity (IEI), formerly referred to as primary immunodeficiencies, manifest with a wide range of symptoms such as increased susceptibility to infections, immune dysregulation, and autoinflammation. Although most cases manifest in childhood, onset during the neonatal period is rare but potentially critical.
Summary: In this review, we discuss the diverse clinical presentations of IEI and the specific challenges they pose to neonatologists.
Background: Vaccinations represent an easily accessible, safe, and important method for preventing infections. Patients with primary immunodeficiencies (PID) are more susceptible to infections and should receive an extended spectrum of immunizations in many countries.
Methods: Between January 2019 and May 2020, vaccination certificates of 70 patients with PID from the regions of Würzburg and Hanover in Germany were evaluated.
Article Synopsis
- The study investigates Antibiotic-Refractory Lyme Arthritis (ARLA), focusing on the complex T cell responses that initially target the Lyme bacteria and potentially shift to attacking the body's own proteins, but the exact mechanisms remain unclear.
- Researchers utilized flow cytometry, T cell receptor sequencing, and single-cell RNA sequencing to analyze T helper cells from patients' inflamed joints in Europe, discovering a specific TCR-β motif linked to ARLA that was not common in North American patients.
- The findings reveal a distinct TCR response in ARLA patients that drives the growth of pathogenic T helper cells, providing insights into the immune system's maladaptive responses and aiding future identification of key antigens involved in