[Principles and problems in the epidemiology of multiple sclerosis].

The problems of epidemiological studies in multiple sclerosis (MS) concern: the (1.) difficulties of diagnostics, the (2.) development and heterogeneity of the disease (manifestation and forms of course), the (3.

Immunodiagnostic of multiple sclerosis by estimation of lymphokines in vitro and in vivo.

The basis of our investigations is a hypothesis about immunomechanisms responsible for aetiopathogenesis of multiple sclerosis including immungenetic connection (predisposition) and autoimmunity (pathogenesis). Some new results about cellular immunity using cell electrophoresis mobility technique, especially sensitization against normal brain tissue antigen (NTA) and investigations of lymphokines in cerebrospinal fluid are represented. The intention of this paper is to demonstrate a combined diagnostic regime for early detection of multiple sclerosis as well as for follow-up studies in course of treatment.