Publications by authors named "H J Metselaar"

Pregnancy after orthotopic liver transplantation (OLT) puts the mother, child, and transplanted organ at risk. Little is known about long-term outcomes. We performed a nationwide retrospective cohort study to evaluate short-term and long-term outcomes of post-OLT pregnancies.

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Background & Aims: Tacrolimus has been associated with recurrence of primary biliary cholangitis (PBC) after liver transplantation (LT), which in turn may reduce survival. This study aimed to assess the association between the type of calcineurin inhibitor used and long-term outcomes following LT in patients with PBC.

Methods: Survival analyses were used to assess the association between immunosuppressive drugs and graft or patient survival among adult patients with PBC in the European Liver Transplant Registry.

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Article Synopsis
  • A multicenter, randomized controlled study aimed to assess the impact of LCP-tacrolimus versus ER-tacrolimus on the development of posttransplant diabetes, hypertension, and chronic kidney disease (CKD) in liver transplant recipients over 12 months.
  • The study involved 105 patients, and results showed that a lower percentage of those on LCP-tacrolimus experienced the combined health issues compared to those on ER-tacrolimus, with statistically significant results.
  • Overall, LCP-tacrolimus demonstrated a notable reduction in the prevalence of these conditions without affecting rejection rates or overall survival compared to ER-tacrolimus.
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Purpose: The popularity of direct oral anticoagulants (DOACs) is increasing among patients with cirrhosis. Cirrhosis has a major impact on the pharmacokinetics of drugs, potentially increasing adverse events. Safe use of drugs in cirrhosis requires a diligent risk-benefit analysis.

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