Junctional adhesion molecule C expression specifies a CD138low/neg multiple myeloma cell population in mice and humans.

Deregulation such as overexpression of adhesion molecules influences cancer progression and survival. Metastasis of malignant cells from their primary tumor site to distant organs is the most common reason for cancer-related deaths. Junctional adhesion molecule-C (JAM-C), a member of the immunoglobulin-like JAM family, can homodimerize and aid cancer cell migration and metastasis.

Transient regulatory T-cell targeting triggers immune control of multiple myeloma and prevents disease progression.

Multiple myeloma remains a largely incurable disease of clonally expanding malignant plasma cells. The bone marrow microenvironment harbors treatment-resistant myeloma cells, which eventually lead to disease relapse in patients. In the bone marrow, CD4FoxP3 regulatory T cells (Tregs) are highly abundant amongst CD4 T cells providing an immune protective niche for different long-living cell populations, e.

A Hyperactive Form of the Zinc Cluster Transcription Factor Stb5 Causes Overexpression and Beauvericin Resistance in Candida albicans.

Gain-of-function mutations in the zinc cluster transcription factors Mrr1, Tac1, and Upc2, which result in constitutive overexpression of their target genes, are a frequent cause of fluconazole resistance in the pathogenic yeast In this study, we show that an activated form of another zinc cluster transcription factor, Stb5, confers resistance to the natural compound beauvericin via the overexpression of , encoding an efflux pump of the ATP-binding cassette transporter superfamily. Beauvericin was recently shown to potentiate the activity of azole drugs against Although Yor1 did not contribute to fluconazole resistance when cells were treated with the drug alone, Stb5-mediated overexpression diminished the synergistic effect of the fluconazole-beauvericin combination, thereby enhancing fluconazole resistance in beauvericin-treated cells. Stb5-mediated overexpression also suppressed the inhibition of hyphal growth, an important virulence trait of , by beauvericin.

Prevalence and determinants of diabetes mellitus and impaired glucose tolerance in Indonesia (a part of basic health research/Riskesdas).

Aim: To estimate the prevalence of diagnosed and undiagnosed diabetes mellitus (DM) and impaired glucose tolerance (IGT) in 15 year old and over in urban Indonesia and their association with risk factors such as age, smoking, physical inactivity, obesity, hypertension.

Methods: A national sample involving 24,417 participants living in urban Indonesia aged > 15 years were examined for 2 hours of plasma glucose concentrations in a cross sectional survey using the 75-g oral glucose. Diagnostic criteria of the World Health Organization 1999 and American Diabetes Association (ADA) 2003 were used to determine the prevalence of abnormal glucose tolerance.